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TPOAbs and or thyroglobulin antibodies, TgAbs) in iodine-sufficient areas. In Brussels for instance before iodine supplementation was systematically prescribed, almost 10% of women developed a goiter during pregnancy, which was only partially reversible after parturition (31). Clin Endocrinol 1998; 49:325-9 354 Yeo CP, Khoo DH, Eng PH, Tan HK, Yo SL, Jacob E.

Pregnancy has profound effects on the regulation of thyroid function in healthy women and patients with thyroid disorders. It is of interest that there is an increase in infertility in women with endometriosis [RR 3. The thyrotropic role of hCG in normal pregnancy is illustrated in fig 14- 4. J Clin Endocrinol Metab1992:;74: 645-53 410 Kokandi AA Parkes AB, Premawardhana LD, John R, Lazarus JH. Ong GS, Hadlow NC, Brown SJ, Lim EM, Walsh JP.



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First- and second-trimester thyroid hormone reference data in pregnant women: a FaSTER (First- and Second-Trimester Evaluation of Risk for aneuploidy) Research Consortium study. The results of such studies have indicated that pregnant women who reside in severely iodine-deficient regions can adequately be managed with iodine supplementation. Meanwhile, optimal cooperation and communication between endocrinologists and obstetricians is also necessary.

Pop VJ, Brouwers EP, Wijnen H, Oei G, Essed GG, Vader HL. Effects of maternal hypothyroidism on offspring hippocampus and memory. Messuti I, Corvisieri S, Bardesono F, Rapa I, Giorcelli J, Pellerito R, Volante M, Orlandi F. Mil NH, Tiemeier H, Bongers-Schokking JJ, Ghassabian A, Hofman A, Hooijkaas H, Jaddoe VW, de Muinck Keizer-Schrama SM, Steegers EA, Visser TJ, Visser W, Ross HA, Verhulst FC, de Rijke YB, Steegers-Theunissen RP. Physiological amounts of free T4 are present in coelomic and amniotic fluids surrounding the developing embryo already in first trimester.


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